![]() ![]() Our technique enables effective categorization and visualization of mutations by using specifically-arranged mutation matrices. Results show the emergence of distinct patterns not immediately discernible from the raw matrices. To illustrate the capabilities of our approach, the technique is used to visualize and to compare mutation patterns in evolving sequences with diametrically opposite characteristics. The magnitude and frequences of mutations for an alignment are subsequently described using color information and scaling factors. To categorize the mutations, amino acids in a mutation matrix are arrang according to one of three sets of physicochemical characteristics, namely hydrophilicity, size and polarizability, and charge and polarity. Here, we describe a tool where such mutations are efficiently identified, categorized and visualized. It is useful to develop a tool that would effectively describe protein mutation matrices specifically geared towards the identification of mutations that produce either wanted or unwanted effects, such as an increase or decrease in affinity, or a predisposition towards misfolding. ![]()
0 Comments
Leave a Reply. |
Details
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |